In the first Nights, the Clan was fairly centered around its Antediluvian and, not surprisingly, Egypt. Many different tales are told about his divinity and how he was cursed by Ra in his struggle against his rival Osiris, whom he eventually managed to kill, and his abandonment by his disciples and fellow Antediluvians. In the manner of the Path of Typhon, all these accounts are taken for true, because limitation to just one version is just another sign of the influence of Ra and Osiris in this world.

It can be said that Set's get had a fairly great influence on Egypt as a whole during the days of pharaonic Egypt, although his efforts were always undermined by the Osirian League under the leadership of his eternal enemy Horus. Set himself guided his Clan from his great temple in Ombos and sometimes got involved personally with dethroning pharaohs who were to entrenched by Ma'at and the schemes of the Aeons. In this way, the Followers of Set established their hold on the lands of Egypt on several times: First during the reign of the Hyksos (in an alliance with the Lasombra), then during the 19th dynasty under Ramesses and during the hellenestic Age under Alexander the Great. During the reign of Rome, the Setites flourished in countless cults among the children of Seth and of Caine, promising ancient secrets and shaping the mindset of their cultists to resist the snares of Ma'at.

All these efforts were delivered a serious blow when Set himself disappeared in 33 CE (the alleged year of Christ's crucification, as some Setites notice). After the departure of the founder, earthquakes shattered Egypt and many of the old temples sunk and became lost, often taking many of the slumbering methuselahs of the clan with them. However, Nakhthorheb and the remaining Hierophants took the reins of the clan, ruling the progeny of Set in his absence.